Molecular library and assay information sites

From LabAutopedia

1 A compilation of external resources on molecular libraries, assays and tools
2 Standards
3 Related articles
- 3.1 Study into the Long-Term Stability of Screening Library CompoundsStored Under Different Conditions
4 Government - United States
5 Academic and non-profit screening centers

A compilation of external resources on molecular libraries, assays and tools

Standards

Microplate Standards - ANSI/Society of Biomolecular Sciences

Since SBS is not a standardizing association, but an association that provides Special Interest Groups the ability and platform to standardize along with ANSI (the American National Standards Institute), in the event that the ANSI/SBS Microplate Standards are to be used in advertisements, product releases, or abstracts, the standards must be referred by:

ANSI/SBS 1-2004: Microplates - Footprint Dimensions
ANSI/SBS 2-2004: Microplates - Height Dimensions
ANSI/SBS 3-2004: Microplates - Bottom Outside Flange Dimensions
ANSI/SBS 4-2004: Microplates - Well Positions
SBS-5 Microplates - Side-Wall Rigidity

Study into the Long-Term Stability of Screening Library CompoundsStored Under Different Conditions

ChemBridge Corporation

ChemBridge are in the fortunate position of having a screening collection of handsynthesised, rare compounds, assembled approximately 5 years ago, that comprises a group of samples made available as dry powders, dry films or as DMSO solutions. The storage of these compounds is typical of that which can be found in many drug discovery environments with DMSO solutions being stored frozen at -18°C under nitrogen and solid (dry powder, dry film) samples stored in the dark at ambient temperature and pressure. ChemBridge have now used this valuable resource of chemically diverse compounds to evaluate the long-term stability of such samples; the results of this study are presented here.

Government - United States

National Institutes of Health (NIH) Roadmap for Medical Research

The NIH Roadmap for Medical Research was launched in September, 2004, to address roadblocks to research and to transform the way biomedical research is conducted by overcoming specific hurdles or filling defined knowledge gaps. Roadmap programs span all areas of health and disease research and boundaries of NIH Institutes and Centers (ICs). These are programs that might not otherwise be supported by the NIH ICs because of their scope or because they are inherently risky. Roadmap Programs are expected to have exceptionally high potential to transform the manner in which biomedical research is conducted. They are also expected to be short term, 5–10 year programs. This incubator space time frame is intended to allow the major roadblocks that were defined for each program to be overcome, thereby stimulating further research conducted through the ICs.

Molecular Libraries Program (MLP) offers public sector biomedical researchers access to the large-scale screening capacity necessary to identify small molecules that can be optimized as chemical probes to study the functions of genes, cells, and biochemical pathways. This will lead to new ways to explore the functions of genes and signaling pathways in health and disease. The flagship of the MLP is the Molecular Libraries Probe Production Centers Network (MLPCN), a network of national laboratories, whose aim is generate novel small molecule probes by performing HTS, secondary screens and medicinal chemistry. The assays for these probes are sourced from the scientific community.
- The MLPCN is composed of three different types of centers:
  - Comprehensive Centers: Provides all three assay, cheminformatics/informatics, and medicinal chemistry, within a single site and a located at Broad, Burnham, NCGC, and Scripps.
  - Specialized Screening Centers: Handles specialized types of assays including handling assay informatics and are located at Johns Hopkins, SRI, and UNM.
  - Specialized Chemistry Centers: Focuses on providing medicinal chemistry and cheminformatics support for performing structure-activity relationships that is typically needed to produce useful chemical probes from screening hits. These are located at Kansas and Vanderbilt.
- Resources of interest to LabAutopedia readers
  - NCGC Assay Guidance Manual: This document is written to provide guidance to investigators that are interested in developing assays useful for the evaluation of compound collections to identify chemical probes that modulate the activity of biological targets. Originally written as a guide for therapeutic projects teams within a major pharmaceutical company, this manual has been adapted to provide guidelines for:
National Centers for Biomedical Computing: Are cooperative agreement awards that are funded under the NIH Roadmap for Bioinformatics and Computational Biology. The Centers are intended to be the core of the networked national effort to build the computational infrastructure for biomedical computing in the nation, the National Program of Excellence in Biomedical Computing (NPEBC). There are seven funded Centers that cover systems biology, image processing, biophysical modeling, biomedical ontologies, information integration, and tools for gene-phenotype and disease analysis.

The Biomarkers Consortium

Foundation for the National Institutes for Health

The Biomarkers Consortium is a public-private biomedical research partnership managed by the Foundation for the National Institutes of Health (FNIH) that endeavors to develop, validate, and qualify biological markers (biomarkers) to speed the development of medicines and therapies for detection, prevention, diagnosis, and treatment of disease and improve patient care.

Developmental Therapeutics Program - (National Cancer Institute (NCI) / National Institutes of Health (NIH))

As the drug discovery and development arm of the National Cancer Institute, the Developmental Therapeutics Program (DTP) plans, conducts, and facilitates development of therapeutic agents for cancer and AIDS. The (DTP) operates a progressive, tiered in vitro and in vivo anti-cancer compound screening program for single pure compounds with the goal of identifying and evaluating novel chemical leads and biological mechanisms of action. The program does not support screening of chemical libraries.