W521:Schenker:The Future Of Compound Management
Dr Richard Kim, Ben Schenker, Simon Tullett.
Current compound management practices have evolved to support both primary and secondary screening projects from a centralized repository storing a combination of plates and tubes.
Storage of both tube and plate formats is an inefficient design and adds to the complexity of these repositories, making them expensive to implement and more importantly difficult to expand or relocate. Also, new sample submission becomes a protracted process, which can lead to delays of several months until the samples are available for HTS.
Plates are considered the only way to support the throughput requirements of primary screening, but they also compromise sample integrity by introducing uncontrolled exposure to the environment and multiple freeze/thaw cycles. In addition, quality control of plate based material is almost impossible causing false positives and negatives, which are not picked up until the secondary screening stage.
Plates also limit the flexibility of a library, requiring the entire library to be screened in each HTS campaign. A more efficient approach to primary screening would be to only screen against library subsets that are chemically relevant to the target, but this would require ultra high throughput cherry-picking of tubes.
In this poster we will describe an innovative large-scale tube-based compound management approach to maximize lab space; improve compound stability; enable rapid generation of custom screening sets; while providing background QC and real time library integration of new chemical entities.
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