From the SLAS2015 Innovation AveNEW
Telos Scientific is one of the participants in the 2015 Innovation AveNEW program. This article provides an overview of the company and their offering.
Telos Scientific is a full service custom automation company operating since 2010 to advance and support laboratory automation. Telos has been very successful with its development, sales and support of the novel and innovative artificial intelligence (AI) driven software platform AutoPilot.
AutoPilot allows scientists to operate complex and fully integrated automation systems in the complete absence of programming knowledge. For more complex scientific tasks such as sample preparation for pharmacokinetic (PK) analysis, AutoPilot utilizes modules which interface with LIMS to further streamline and simplify involved, repetitive and error-prone procedures. It is this newly developed, validated and operational AutoPilot driven PK module (PKmod) which was highlighted at SLAS2015 in the innovation AveNEW program.
Modern labs require sophisticated tools to perform scientific protocols of ever increasing complexities. The implementation of high level automation shifts focus from the scientific task at hand to the complexities of using the automation tool or system. AutoPilot utilizes novel AI to “interpret” what the scientist needs to do and then dynamically executes optimal automated processes utilizing the resources (e.g. liquid handlers, incubators, labware) that are available in the lab. In this way AutoPilot flips the orthodoxy such that end user scientists are empowered to simply use the tool/system and focus on their research.
Biological sample preparation for PK analyses is essential in all of drug discovery and presents both technical and logistic challenges. Samples initially undergo a minimum required dilution (MRD) followed by various assay specific dilutions before being formatted with standards and controls onto assay plates for analyses. Previous strategies to accommodate this variability have used worklist driven pipetting to provide instruction for each aspirate and dispense command in the series for each sample. These worklists needed to be generated for each run which includes defining the necessary dilution scheme for each sample and inputting all required volumes to achieve it. As one could imagine, manual PK sample preparations are both labor intensive and error prone.
The PK module eliminates the need for these manual manipulations by employing AutoPilot’s AI which interprets LIMS/LIS provided specifications (e.g. Watson, Gyros) and dynamically directs downstream liquid handling. It independently determines optimal dilution schemes and volumes, mixing dynamics, tip usage and final plate aliquoting. The module directs the performance of any or all of 4 PK analysis processes; i) assay MRD, ii) sample dilution, iii) pre-assay plate formatting and iv) a time=0 stamp onto a final assay plate. This eliminates the need for user defined worklists, minimizes human error, and shifts the operator's time to higher order scientific analyses. AutoPilot and the PK module were not designed to simplify traditional programming requirements but instead to eliminate them and provide the scientists time to do science.