Robust nanoliter liquid handling for flexible assay miniaturisation
Joby Jenkins, Ben Schenker, Rob Lewis, Chloe Carter
Serial dilutions, plate replications and reformatting into higher density plates are important and often routine processes in drug discovery but, when assay volumes are miniaturised to nanolitre levels, there are some significant challenges to be met in the process of automating them. Miniaturised assays have important cost benefits in the reduction of precious compounds and reagents required, but it is paramount to maintain speed, accuracy and precision at these volumes or the efficiencies achieved become outweighed by the disadvantages. Miniaturising assays also allows users to draw on a wider range of high density plates for further efficiencies, but these often present challenges for liquid handling systems.
mosquito® HTS (TTP LabTech) is a nanolitre liquid handler flexible enough to automate the miniaturisation of all standard HTS assays without needing special labware or system set-up changes. It offers extremely fast and accurate plate replication and serial dilutions. It is also capable of reformatting between different plate types in the same protocol – even from standard 96-well formats direct to high density 1536-well plates.
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