T322:Jenkins:An Integrated Solution for Automated Nanoliter Hit-Picking
Joby Jenkins1, Stephen Starkie1, Chloe Carter1, Manuel Baader2
1 TTP Labtech Ltd, 2 BioFocus
A prerequisite for efficient primary screening is rapid, automated selection of “hits” for confirmation and secondary profiling. The mosquito® X1 offers precision sampling of any individual well in 48-, 96-, 384-or 1536-well plates. This enables researchers to quickly select small volumes of hits from a variety of primary screening plates and transfer them directly to the next screening stage without further dilution. Mosquito X1’s disposable pipette tips guarantee zero cross-contamination, and their unique positive displacement pipetting technology ensures accurate and reproducible pipetting throughout the 25 nL -1.2 μL range.
This poster describes a section of BioFocus’s screening workfolow where mosquito X1 is integrated with a RapidStak plate stacker (Thermo Scientific) using TTP LabTech’s CherryPicker software. This allows the mosquito X1 to work unattended for extended periods. The CherryPicker software drives the system automatically by converting pick lists provided by BioFocus’ LIMS system into mosquito protocols, and feeding appropriate plates via the RapidStak. The software optimises each protocol for efficient pipette use, and, if required, could also track the volumes of the source plates for subsequent reporting back to the LIMS system.
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