Presentations on system acceptance testing

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Presentations on system acceptance testing


Abstracts of presentations hosted on the web site of the Laboratory Robotics Interest Group (LRIG)

Pfizer-REMP Biofluid BioBank Store
John Williams, Ph.D.; Director
Pfizer Global Research & Development

The need, capacity and design of a unique –20°C/-80°C combined automated REMP store for biofluid samples will be presented. The refrigeration design is novel and based on a system developed by Pfizer together with Environmental Specialties Inc. (ESI) for centralized –80°C long-term freezers. REMP has designed unique door access and robot access from a –20°C compartment into the –80°C freezers. A constraint of +/-5°C was imposed on all –80°C operations. The practical impact of this constraint on operational processes will be discussed. Several aspects of the most critical component, the Luwa Environmental Specialties (ESI) cascade freezer systems will be recounted with emphasis on redundancy specifications. Performance data for the operational systems will be discussed to illustrate the time constraints required to remain within the +/- 5°C specification. This aspect has required new REMP software incorporating a novel algorithm for optimal access to the multiple freezers to fulfill a single order across multiple storage racks. Furthermore a specific loading algorithm has been added to ensure all samples are loaded from the bottom of freezers to maximize sample cooling in partial freezers.
DNA samples are stored in the –20°C compartment that is a standard REMP store. DNA samples are thawed and refrozen after each access and are in the proprietary REMP 96-well 900ul tubes. Individual samples are replaced in their original locations to prevent store fragmentation. In contrast biofluid samples are in the same tubes but heat-sealed and used as single use samples to minimize freeze/thaw cycles.
The timelines for design, manufacture, and installation, will be presented. A number of functionalities that were developed for the earlier REMP stores and their reuse will be discussed, together with the rationale for a partial FAT at Oberdiessbach will be presented with respect to reduced time and cost versus potential issues.

An Automated Approach to the Supply of Samples for Screening
Terry Wood, Pfizer Global Research & Development, Sandwich, UK

Project plan, Factory Acceptance Testing (FAT) and Site Acceptance Testing (SAT)

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