SLAS

Poster: Layer-by-Layer Chitosan-Alginate Coating of Polymeric Nanoparticles for Colon Specific Drug Delivery

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Poster presentation at SLAS2014.
Winner of a SLAS Young Scientist Award.

Garrett Mosley
Graduate Student Researcher, UCLA Department of Bioengineering

Abstract

Colon specific drug delivery is an important criterion for many medical applications including treatment of inflammatory bowel disease (IBD) and colon cancer. The ability to prevent premature drug release during transit through the gastrointestinal tract is beneficial both because it reduces the amount of drug that is wasted and also because it prevents adverse side effects. One method for achieving colon specific drug delivery is through the application of a pH responsive enteric coating, which is designed to prevent drug release at more acidic pH levels and allow normal drug release at basic pH levels, which are indicative of gastric and colonic environments, respectively. One potential formulation is a chitosan-alginate coating, which has previously been used for drug release from nanotubes. In this study, we applied alternating layers of chitosan and alginate to poly(lactic-co-glycolic acid) nanoparticles, which are potential delivery vehicles for IBD and colon cancer treatment. Alternating zeta potential measurements suggest successful application of each subsequent layer. We demonstrate that this coating delays drug release in a manner that is dependent on the pH of the environment, suggesting that this enteric coating system could be effective in colon specific drug delivery. Having the ability to specifically deliver drugs to the colon is a useful tool especially in regards to treatment of IBD or colon cancer. In the future, we would like to conjugate targeting ligands to the nanoparticles prior to coating and assess their efficacy as delivery vehicles for the purpose of IBD and cancer treatment.