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MP22: Biomimetic System for Circulating Tumor Cell Isolation

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 Cari Launiere, Gregory J. Czaplewski, Ja Hye Myung*, Seungpyo Hong* and David T. Eddington

Department of Bioengineering, University of Illinois, Chicago, Illinois
*Department of Biopharmaceutical Sciences, University of Illinois, Chicago, Illinois

Microfluidic CTC isolation devices (MCIDs) are used to remove cancer cells from patient blood samples for the purposes of cell enumeration or molecular characterization. The information collected can be used for the monitoring of disease progression or for basic research. While some devices are already being used in a clinical setting, there is still much room for improvement in terms of cost, efficiency and ease of use. We have developed a system that combines biomimetic protein combinations, hydrophoretic cell focusing, and microscope interface features within one inexpensive and easily fabricated device. Improvements to the validation procedure, such as the use of biomimetic rheological test solutions and automation of the enumeration procedure, allow for rapid benchmarking of new device designs.

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