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LabAutopedia:MainOutline

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Contents

What is Laboratory Automation

  1. http://en.wikipedia.org/wiki/Laboratory_automation

 Practicing laboratory automation 

  1. List_of_Laboratory_automation_terminology
    1. liquid handler, microplate, ....
  2. Project Management
  3. Choosing the right project
    1. Economic justification
    2. Evaluation of bottlenecks and process flow
      1. Lean sigma approaches to process mapping
  4. Develop strategy and plan
    1. Requirements Document
    2. Design, analysis and simulation
      1. System throughput, capacity, bottlenecks, etc.
  5. Choosing the right technology
    1. Entry points to technology 
  6. Resourcing and executing the project
    1. Automation sourcing
    2. The Lab Automation expert
      1. Academic programs
  7. Build vs. Buy
  8. System validation
    1. Acceptance testing
    2. Regulatory compliance
  9. On-going operation and support
    1. Quality programs in lab automation 

Laboratory automation system architectures

  1. Laboratory Unit Operation (LUO) concept
    1. Sample transport
    2. Sample processing
    3. Data collection and processing
  2. Automating LUO's: Strategy and scale
    1. Sample transport technology
      1. Robotic Transport
      2. Fluidic Transport
      3. Actuators
      4. Sample vessels
        1. The Array concept
  3. Electronic interfaces
  4. Programming Automation
    1. Command Languages
    2. Programming Motions
    3. Method Programming
    4. Script Engines
    5. Visual Programming
    6. Automatic Programming
  5. Error handling

Sample processing

  1. Dispensing of solids
  2. Centrifuging
  3. Mixing
  4. Incubation
  5. Liquid Handling: Theory and Practice
  6. Fluid channel processing
  7. Etc.

Data collection and processing technology

  1. Detection Technologies
    1. Absorbance
    2. Fluorescence Polarization
    3. Time Resolved Fluorescence
    4. Fluorescence Ionization
    5. Luminescence
    6. Homogeneous Time-Resolved Fluorescence
  2. Sensors and Signal Conditioning
    1. Sensor Types
      1. Mechanical
      2. Electromechanical
      3. Optical
      4. Acoustic
      5. Capacitive
      6. Electromagnetic
      7. Motion
      8. Distance
      9. Thermal
      10. Inductive
      11. Level Sensor
    2. Signal Conditioning
      1. Analog to Digital conversion
  3. Automated ID Technologies
    1. Laboratory Use 
      1. Accuracy of data input
        1. Speed of Data Entry
        2. Timeliness of Data Input
        3. Labor Savings and Cost Efficiency
      2. Sample, reagent, or equipment identifiers
      3. Personnel identification
      4. Instructions, procedure, and data entry
    2. Strategy
      1. Information Container
      2. Pointer to Information (license plate model)
    3. Types of Automated ID
      1. Bar Codes
      2. Radio Frequency ID (RFID)
      3. Optical Character Recognition (OCR)
      4. Biometrics
  4. Imaging
    1. Image Capture
    2. File Formats
    3. Image Analysis
      1. Thresholding
      2. Blob/Particle Finding
      3. Watershed Algorithm
  5. Data Management
    1. Laboratory Data Types
    2. Data Storage Technologies
      1. Primary Storage
      2. Secondary Storage
      3. Tertiary Storage
      4. Offline Storage
      5. Hierarchical Storage Management
    3. Organizing Laboratory Data
      1. Files
        1. Plain Text File
        2. Structured Text File
        3. File Attributes
        4. File Systems
      2. Relational Databases
      3. Formats and Standards
        1. Extensible Markup Language
        2. Analytical File Format Standards
          1. AnIML
          2. ...
        3. Chemical Structure Formats
          1. Mol files
          2. SMILES/SMARTS
          3. ...
    4. Transmitting laboratory Data
      1. Network Copy
      2. File Transfer Protocol
      3. Web Protocols
    5. Laboratory Data Management Applications
      1. LIMS
      2. Chemical Information Repositories
      3. Screening Data Repositories
      4. ...
  6. Data Analysis
    1. Screening Data
      1. Signal to background
      2. Measurement of separation (Z' statistic)
      3. Quality Control
    2. General Techniques
      1. Analysis of Variance (ANOVA)
      2. Principal Components Analysis
      3. ...
    3. Data visualization
    4. Etc.
  7. Artificial Intelligence
    1. Neural Networks
    2. Genetic Algorithms
    3. Fuzzy Analysis
    4. Self Organizing Maps
    5. Hierarchical Clustering

Application areas

  1. High Throughput Screening
  2. High Throughput Chemistry
  3. Microfluidics
  4. Microarrays
  5. Molecular Diagnostics
  6. NanoBiotechology
  7. Cellular imaging - HCS
  8. Protein Crystallography
  9. Etc.

The Association for Laboratory Automation (ALA)

Lists

Lab Automation Terminology

Journals and Periodicals

Books

Useful websites